Recombinant human VEGFD protein (ab125747)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    HEK 293 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      12 kDa
    • 領域
      93 to 201
    • タグ
      His tag C-Terminus

特性

Our Abpromise guarantee covers the use of ab125747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The ED50 of 3-4ng/ml is measured by its ability to stimulate the proliferation of Human microvascular endothelial cells (HMVECs).
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    ab125747 was lyophilized after extensive dialysis against PBS.
  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    Constituent: 99% PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成
    It is recommended to reconstitute the ab125747 in sterile ultra pure water not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. Upon reconstitution ab125747 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

関連情報

  • 別名
    • c-fos induced growth factor
    • c-fos induced growth factor (vascular endothelial growth factor D)
    • c-fos-induced growth factor
    • FIGF
    • Vascular endothelial growth factor D
    • Vascular endothelial growth factor D precursor
    • VEGF D
    • VEGF-D
    • VEGFD
    • VEGFD_HUMAN
    see all
  • 機能
    Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
  • 組織特異性
    Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
  • 配列類似性
    Belongs to the PDGF/VEGF growth factor family.
  • 翻訳後修飾
    Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • 細胞内局在
    Secreted.
  • Information by UniProt

参考文献

ab125747 has not yet been referenced specifically in any publications.

レビューと Q&A

Unfortunately, we have not tested this product's ability to induce phosphorylation of VEGFR2 and so we do not know whether it is capable of doing so.

We have only tested it's ability to stimulate the proliferation of Human microvascular endot...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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