Recombinant Human UNC5B protein (ab109066)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来HEK 293 cells
  • アミノ酸配列
    • アクセッション番号Q8IZJ1
    • 生物種Human
    • 分子量80 kDa
    • 領域28 to 363

特性

Our Abpromise guarantee covers the use of ab109066 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • エンドトキシン・レベル< 0.100 Eu/µg
  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Lyophilised
  • 備考Binds to Mouse and Human Netrin 1.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

  • 再構成Reconstitute with 50 µl sterile water.

関連情報

  • 別名
    • 6330415E02Rik
    • A630020F16
    • D10Bwg0792e
    • Netrin receptor UNC5B
    • Netrin receptor UNC5B Precursor
    • p53 regulated receptor for death and life
    • p53 regulated receptor for death and life protein 1
    • p53-regulated receptor for death and life protein 1
    • p53RDL1
    • Protein unc-5 homolog 2
    • Protein unc-5 homolog B
    • Protein XUNC 5
    • Transmembrane receptor Unc5H2
    • Unc 5 homolog 2
    • Unc 5 homolog B
    • Unc 5 netrin receptor B
    • UNC 5B
    • Unc5 (C.elegans homolog) b
    • Unc5b
    • UNC5B_HUMAN
    • UNC5H2
    see all
  • 機能Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • 組織特異性Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
  • 配列類似性Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • 翻訳後修飾Phosphorylated on cytoplasmic tyrosine residues.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
    Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • 細胞内局在Cell membrane. Membrane raft. Associated with lipid rafts.
  • Information by UniProt

Recombinant Human UNC5B protein (ab109066) 使用論文

ab109066 has not yet been referenced specifically in any publications.

Product Wall

I can confirm that is ab109066 an Fc-Protein. The extracellular region of human UNC5B (aa 28-363) is fused at the C-terminus to the Fc portion of human IgG1.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"