製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q05086
    • 生物種Human
    • 領域342 to 585

特性

Our Abpromise guarantee covers the use of ab126020 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成Reconstitute with water to desired concentration.

関連情報

  • 別名
    • ANCR
    • Angelman syndrome
    • AS
    • CTCL tumor antigen se37 2
    • CTCL tumor antigen se37-2
    • E6 AP
    • E6AP
    • E6AP ubiquitin protein ligase
    • E6AP ubiquitin-protein ligase
    • EPVE6AP
    • FLJ26981
    • HECT-type ubiquitin transferase E3A
    • HPVE6A
    • Human papilloma virus E6 associated protein
    • Human papilloma virus E6 associated protein Angelman syndrome
    • Human papillomavirus E6-associated protein
    • NY REN 54 antigen
    • Oncogenic protein associated protein E6 AP
    • Oncogenic protein associated protein E6AP
    • Oncogenic protein-associated protein E6-AP
    • Renal carcinoma antigen NY REN 54
    • Renal carcinoma antigen NY-REN-54
    • UBE 3A
    • Ube3a
    • UBE3A protein
    • UBE3A_HUMAN
    • Ubiquitin protein ligase E3A
    • Ubiquitin-protein ligase E3A
    see all
  • 機能E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
  • パスウェイProtein modification; protein ubiquitination.
  • 関連疾患Angelman syndrome
  • 配列類似性Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • 翻訳後修飾Phosphorylation at Tyr-659 by ABL1 impairs E3 ligase activity and protects p53/TP53 from degradation in (HPV)-infected cells.
  • 細胞内局在Nucleus. Cytoplasm.
  • Information by UniProt

Recombinant Human UBE3A protein (ab126020) 使用論文

ab126020 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"