製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNSN VENLPPHIIR LVYKEVTTLT ADPPDGIKVF PNEEDLTDLQ VTIEGPEGTP YAGGLFRMKL LLGKDFPASP PKGYFLTKIF HPNVGANGEI CVNVLKRDWT AELGIRHVLL TIKCLLIHPN PESALNEEAG RLLLENYEEY AARARLLTEI HGGAGGPSGR AEAGRALASG TEASSTDPGA PGGPGGAEGP MAKKHAGERD KKLAAKKKTD KKRALRRL

特性

Our Abpromise guarantee covers the use of ab87756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab87756 was purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

関連情報

  • 別名
    • AA409170
    • E2 EPF
    • E2-EPF
    • E2EPF
    • EPF5
    • MGC101982
    • Ube2s
    • UBE2S_HUMAN
    • Ubiquitin carrier protein S
    • Ubiquitin conjugating enzyme E2 24 kD
    • Ubiquitin conjugating enzyme E2 24 kDa
    • Ubiquitin conjugating enzyme E2 EPF5
    • Ubiquitin conjugating enzyme E2 S
    • Ubiquitin conjugating enzyme E2S
    • Ubiquitin protein ligase S
    • Ubiquitin-conjugating enzyme E2 S
    • Ubiquitin-conjugating enzyme E2-24 kDa
    • Ubiquitin-conjugating enzyme E2-EPF5
    • Ubiquitin-protein ligase S
    see all
  • 機能Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Belongs to the ubiquitin-conjugating enzyme family.
  • 翻訳後修飾Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
  • Information by UniProt

Recombinant Human UBE2S protein 画像

  • 15% SDS-PAGE analysis of 3µg ab87756.

Recombinant Human UBE2S protein (ab87756) 使用論文

ab87756 has not yet been referenced specifically in any publications.

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