Recombinant Human Tropomyosin 3 protein (ab112675)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P06753
    • 生物種Human
    • 分子量41 kDa

特性

Our Abpromise guarantee covers the use of ab112675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    pH: 6.80
    Constituents: 1.58% Tris HCl, 3.09% DTT, 4% SDS, 0.2% Bromophenol blue, 20% Sucrose

  • 再構成Add 200ul of distilled water.

関連情報

  • 別名
    • Alpha tropomyosin 3
    • Alpha tropomyosin slow skeletal
    • CFTD
    • Cytoskeletal tropomyosin TM30
    • FLJ41118
    • gamma TM
    • Gamma tropomyosin
    • Gamma-tropomyosin
    • Heat stable cytoskeletal protein 30 kDa
    • hscp30
    • hTM30nm
    • hTM5
    • hTMnm
    • MGC102590
    • MGC14582
    • MGC3261
    • MGC72094
    • NEM1
    • OK/SW-cl.5
    • OTTHUMP00000034019
    • OTTHUMP00000034171
    • OTTHUMP00000034172
    • TM 5
    • TM-5
    • TM3
    • TM30
    • TM30nm
    • TM5
    • Tm5NM
    • Tpm 5
    • TPM3
    • TPM3/NTRK1 FUSION GENE, INCLUDED
    • TPM3_HUMAN
    • Tpm5
    • TPMsk3
    • TRK
    • TRK ONCOGENE, INCLUDED
    • Trop 5
    • Tropomyosin 3
    • Tropomyosin 3 gamma
    • Tropomyosin 5
    • Tropomyosin alpha 3 chain
    • Tropomyosin alpha-3 chain
    • Tropomyosin gamma
    • Tropomyosin-3
    • Tropomyosin-5
    see all
  • 機能Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
  • 関連疾患Defects in TPM3 are the cause of nemaline myopathy type 1 (NEM1) [MIM:609284]. A form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Autosomal dominant nemaline myopathy type 1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate-to-severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
    Defects in TPM3 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TPM3 is found in thyroid papillary carcinomas. A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.
  • 配列類似性Belongs to the tropomyosin family.
  • ドメインThe molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • 細胞内局在Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant Human Tropomyosin 3 protein (ab112675) 使用論文

ab112675 has not yet been referenced specifically in any publications.

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