The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml.
This protein is best used within three months from the date of receipt.
Concentration information loading...
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
E3 ubiquitin protein ligase TRIM37
E3 ubiquitin-protein ligase TRIM37
Mulibrey nanism gene
Mulibrey nanism protein
RING B box coiled coil protein
Tripartite motif containing 37
Tripartite motif containing 37 protein
Tripartite motif containing protein 37
Tripartite motif-containing protein 37
機能E3 ubiquitin-protein ligase.
パスウェイProtein modification; protein ubiquitination.
関連疾患Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
配列類似性Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 MATH domain. Contains 1 RING-type zinc finger.
細胞内局在Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.