製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q96RU7
    • 生物種Human
    • 配列MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPL SPPTAPDRATAVATASRLGPYVLLEPEEGGRAYRALHCPTGTEYTCKVYP VQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRS RHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVL ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVA LFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREP AERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEG DREVVLYG
    • 分子量65 kDa including tags
    • 領域1 to 358

特性

Our Abpromise guarantee covers the use of ab112420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

関連情報

  • 別名
    • C20orf97
    • Neuronal cell death inducible putative kinase
    • Neuronal cell death-inducible putative kinase
    • NIPK
    • p65 interacting inhibitor of NF-kappaB
    • p65-interacting inhibitor of NF-kappa-B
    • SINK
    • SKIP 3
    • SKIP3
    • TRB 3
    • TRB-3
    • TRB3
    • TRIB 3
    • Trib3
    • TRIB3_HUMAN
    • Tribbles homolog 3
    • Tribbles pseudokinase 3
    • Tribbles3
    see all
  • 機能Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
  • 組織特異性Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human TRIB3 protein 画像

  • ab112420 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human TRIB3 protein (ab112420) 使用論文

ab112420 has not yet been referenced specifically in any publications.

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