Recombinant Human Transportin 1 protein (ab114514)

製品の概要

  • 製品名Recombinant Human Transportin 1 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q92973-2
    • 生物種Human
    • 配列PDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKN NVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQ NWPDLLPKLCSLLDSED*
    • 分子量39 kDa including tags
    • 領域25 to 141

特性

Our Abpromise guarantee covers the use of ab114514 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Importin 2
    • Importin beta 2
    • Importin beta-2
    • IPO 2
    • IPO2
    • Karyopherin (importin) beta 2
    • Karyopherin beta 2
    • Karyopherin beta-2
    • KPN B2
    • KPNB 2
    • KPNB2
    • M9 interacting protein
    • M9 region interacting protein
    • M9 region interaction protein
    • MIP
    • MIP 1
    • MIP1
    • OTTHUMP00000126960
    • OTTHUMP00000222024
    • OTTHUMP00000226224
    • TNPO 1
    • Tnpo1
    • TNPO1_HUMAN
    • Transportin
    • Transportin 1
    • Transportin-1
    • Transportin1
    • TRN
    see all
  • 機能Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
  • 配列類似性Belongs to the importin beta family.
    Contains 8 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human Transportin 1 protein 画像

  • ab114514 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human Transportin 1 protein (ab114514) 使用論文

ab114514 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"