製品の概要

  • 製品名Recombinant Human TNNC1 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P63316
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMDDIYKAAVEQLTEEQKNEFKAAFDIFVLG AEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVM MVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITE DDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
    • 分子量21 kDa including tags
    • 領域1 to 161
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab113126 was purified using conventional chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • Cardiac troponin C
    • CMD1Z
    • CMH13
    • slow skeletal and cardiac muscles
    • Slow twitch skeletal/cardiac muscle troponin C
    • TN-C
    • TNC
    • TNNC
    • Tnnc1
    • TNNC1 troponin C type 1 (slow)
    • TNNC1_HUMAN
    • Troponin C
    • troponin C type 1 (slow)
    • Troponin C, slow skeletal and cardiac muscles
    • Troponin C1, slow
    see all
  • 機能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • 関連疾患Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of cardiomyopathy familial hypertrophic type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 配列類似性Belongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt

Recombinant Human TNNC1 protein 画像

  • 15% SDS-PAGE analysis of TNNC1 protein (ab113126; 3 µg).

Recombinant Human TNNC1 protein (ab113126) 使用論文

ab113126 has not yet been referenced specifically in any publications.

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