製品の概要
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製品名Recombinant human TNF beta protein
TNF beta タンパク質・ペプチド 製品一覧 -
タンパク質長Full length protein
製品の詳細
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由来Recombinant
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由来Escherichia coli
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アミノ酸配列
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生物種Human
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配列Human TNF-beta is an 18.6 kDa protein containing 172 amino acid residues.: MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFL QDGFSLSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH E VQLFSSQYP FHVPLLSSQKMVYPGLQEPW LHSMYHGAAF QLTQGDQL ST HTDGIPHLVL SPSTVFFGAF AL
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特性
Our Abpromise guarantee covers the use of ab639 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Functional Studies
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エンドトキシン・レベル< 0.100 Eu/µg
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製品の状態Lyophilised
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備考The ED50, determined by the cytolysis of murine L929 cells in the presence of actinomycin D, is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.
n/a
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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再構成Reconstitute with 20µl pure water.
関連情報
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別名
- LTalpha
- DIF
- LT
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機能Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
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関連疾患Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
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配列類似性Belongs to the tumor necrosis factor family.
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細胞内局在Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
- Information by UniProt
参考文献
ab639 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"