Recombinant human TNF beta protein (ab639)

関連情報

• 別名
  • LTalpha
  • DIF
  • LT

  • LT alpha
  • LT-alpha
  • Lta
  • Lymphotoxin alpha
  • Lymphotoxin alpha (TNF superfamily, member 1)
  • Lymphotoxin-alpha
  • TNF B
  • TNF superfamily member 1
  • TNF, lymphocyte-derived
  • TNF-beta
  • TNFB
  • TNFB_HUMAN
  • TNFbeta
  • TNFSF1
  • TNLG1E
  • Tumor necrosis factor beta
  • tumor necrosis factor ligand 1E
  • Tumor necrosis factor ligand superfamily member 1

  see all
• 機能
  Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
• 関連疾患
  Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
• 配列類似性
  Belongs to the tumor necrosis factor family.
• 細胞内局在
  Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.

• Target information above from: UniProt accession P01374 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt