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別名
- LT alpha
- LT-alpha
- Lta
- Lymphotoxin alpha
- Lymphotoxin alpha (TNF superfamily, member 1)
- Lymphotoxin-alpha
- TNF B
- TNF superfamily member 1
- TNF, lymphocyte-derived
- TNF-beta
- TNFB
- TNFB_HUMAN
- TNFbeta
- TNFSF1
- TNLG1E
- Tumor necrosis factor beta
- tumor necrosis factor ligand 1E
- Tumor necrosis factor ligand superfamily member 1
see all
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機能
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
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関連疾患
Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
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配列類似性
Belongs to the tumor necrosis factor family.
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細胞内局在
Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
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Information by UniProt