Recombinant human LTA protein (ab639)
Key features and details
- Expression system: Escherichia coli
- Purity: >= 98% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
製品の詳細
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製品名
Recombinant human LTA protein
TNF beta タンパク質・ペプチド 製品一覧 -
生理活性
The ED50, determined by the cytolysis of murine L929 cells in the presence of actinomycin D, is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg.
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精製度
>= 98 % SDS-PAGE.
Sterile filtered Greater than 98% pure by HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg). -
発現系
Escherichia coli -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFL QDGFSLSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH E VQLFSSQYP FHVPLLSSQKMVYPGLQEPW LHSMYHGAAF QLTQGDQL ST HTDGIPHLVL SPSTVFFGAF AL -
予測される分子量
19 kDa
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製品の詳細
Recombinant human TNF beta protein
特性
Our Abpromise guarantee covers the use of ab639 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Functional Studies
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製品の状態
Lyophilized -
備考
The ED50, determined by the cytolysis of murine L929 cells in the presence of actinomycin D, is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg.This product was previously labelled as TNF beta
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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再構成Reconstitute with 20µl pure water.
関連情報
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別名
- LTalpha
- DAMA-25N12.13-004
- DIF
see all -
機能
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. -
関連疾患
Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). -
配列類似性
Belongs to the tumor necrosis factor family. -
細胞内局在
Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab639 は論文での使用が確認できていません。