製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      LPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPD VFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSF SGVSLFSLSTEGCDEEEV
    • 分子量
      39 kDa including tags
    • 領域
      517 to 634

特性

Our Abpromise guarantee covers the use of ab112363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

    Other

  • 製品の状態
    Liquid
  • 備考
    Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • FLJ10052
    • MGC126430
    • MGC126431
    • SLEB1
    • TIL 3
    • TIL3
    • TLR 5
    • Tlr5
    • TLR5_HUMAN
    • Toll like receptor 5
    • Toll like receptor 5 precursor
    • Toll-like receptor 5
    • Toll/interleukin 1 receptor like protein 3
    • Toll/interleukin-1 receptor-like protein 3
    see all
  • 機能
    Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 組織特異性
    Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
  • 関連疾患
    Systemic lupus erythematosus 1
  • 配列類似性
    Belongs to the Toll-like receptor family.
    Contains 22 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 翻訳後修飾
    Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
    Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • 細胞内局在
    Membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab112363 at approximately 38.61 kDa, stained with Coomassie Blue.

参考文献

ab112363 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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