製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号O60603
    • 生物種Human
    • 配列SHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSL IKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
    • 分子量37 kDa including tags
    • 領域201 to 300

特性

Our Abpromise guarantee covers the use of ab112361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • CD282
    • CD282 antigen
    • TIL 4
    • TIL4
    • TLR 2
    • TLR2
    • TLR2_HUMAN
    • Toll like receptor 2
    • Toll like receptor 2 precursor
    • Toll-like receptor 2
    • Toll/interleukin 1 receptor like 4
    • Toll/interleukin 1 receptor like protein 4
    • Toll/interleukin receptor like protein 4
    • Toll/interleukin-1 receptor-like protein 4
    see all
  • 機能Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
  • 組織特異性Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  • 配列類似性Belongs to the Toll-like receptor family.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 翻訳後修飾Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant Human TLR2 protein 画像

  • ab112361 on a 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human TLR2 protein (ab112361) 使用論文

ab112361 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"