Recombinant Human TICAM2 protein (ab123160)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q86XR7
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MGSHMGIGKS KINSCPLSLS WGKRHSVDTS PGYHESDSKK SEDLSLCNVA EHSNTTEGPT GKQEGAQSVE EMFEEEAEEE VFLKFVILHA EDDTDEALRV QNLLQDDFGI KPGIIFAEMP CGRQHLQNLD DAVNGSAWTI LLLTENFLRD TWCNFQFYTS LMNSVNRQHK YNSVIPMRPL NNPLPRERTP FALQTINALE EESRGFPTQV ERIFQESVYK TQQTIWKETR NMVQRQFIA
    • 分子量29 kDa including tags
    • 領域1 to 235
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab123160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 85 % SDS-PAGE.
    ab123160 was purified using conventional chromatography techniques and is >85% pure by SDS PAGE.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • Putative NF-kappa-B-activating protein 502
    • TCAM2_HUMAN
    • TICAM-2
    • TICAM2
    • TIR containing adapter molecule 2
    • TIR domain containing adaptor protein
    • TIR domain-containing adapter molecule 2
    • TIRAP 3
    • TIRAP3
    • TIRAP3a short form
    • TIRP
    • Toll-like receptor adaptor protein 3
    • Toll/interleukin-1 receptor domain-containing protein
    • TRAM
    • TRIF-related adapter molecule
    see all
  • 機能Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • 組織特異性Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • 配列類似性Contains 1 TIR domain.
  • ドメインThe TIR domain mediates the interaction with TRAF6.
  • 翻訳後修飾Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • 細胞内局在Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt

Recombinant Human TICAM2 protein 画像

  • 15% SDS-PAGE analysis of 3 µg of Human TICAM2 protein (ab123160).
    Note: Molecular size on SDS PAGE will appear higher.

Recombinant Human TICAM2 protein (ab123160) 使用論文

ab123160 has not yet been referenced specifically in any publications.

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