Recombinant Human Thyroid Peroxidase protein (ab73765)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human
    • 分子量101 kDa including tags
    • 配列の追加情報Glycosylated polypeptide chain containing 834 amino acids and having a molecular mass of 92.9 kDa (excluding glycosylation), 101 kDa total mass. The specific sequence information is proprietary.

特性

Our Abpromise guarantee covers the use of ab73765 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab73765 is purified by proprietary chromatographic techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 160mM Sodium chloride, 16mM HEPES, 0.08mM Kl, pH 7.6

関連情報

  • 別名
    • MSA
    • PERT_HUMAN
    • TDH2A
    • Thyroid microsomal antigen
    • Thyroid peroxidase
    • Thyroperoxidase
    • TPO
    • TPX
    see all
  • 機能Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
  • パスウェイHormone biosynthesis; thyroid hormone biosynthesis.
  • 関連疾患Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
    Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
  • 配列類似性Belongs to the peroxidase family. XPO subfamily.
    Contains 1 EGF-like domain.
    Contains 1 Sushi (CCP/SCR) domain.
  • 翻訳後修飾Glycosylated.
    Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
    Cleaved in its N-terminal part.
  • 細胞内局在Membrane and Cell surface.
  • Information by UniProt

Recombinant Human Thyroid Peroxidase protein (ab73765) 使用論文

ab73765 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"