Recombinant Human Thyroid Hormone Receptor beta protein (ab82049)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列の追加情報This protein is His-tagged.

特性

Our Abpromise guarantee covers the use of ab82049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

関連情報

  • 別名
    • Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2
    • C ERBA 2
    • C ERBA BETA
    • c-erbA-2
    • c-erbA-beta
    • ERBA 2
    • ERBA BETA
    • ERBA2
    • Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian
    • generalized resistance to thyroid hormone
    • GRTH
    • MGC126109
    • MGC126110
    • NR1A2
    • Nuclear receptor subfamily 1 group A member 2
    • Oncogene ERBA2
    • PRTH
    • THB_HUMAN
    • THR1
    • thrB
    • THRB 1
    • THRB 2
    • THRB1
    • THRB2
    • Thyroid hormone nuclear receptor beta variant 1
    • Thyroid hormone receptor beta
    • Thyroid hormone receptor beta 1
    • Thyroid hormone receptor beta 2
    • Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian)
    see all
  • 機能High affinity receptor for triiodothyronine.
  • 関連疾患Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human Thyroid Hormone Receptor beta protein 画像

  • SDS-PAGE analysis of Human Thyroid Hormone Receptor beta full length protein (ab82049).

Recombinant Human Thyroid Hormone Receptor beta protein (ab82049) 使用論文

ab82049 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your phone call last week and for your patience while I have been in touch with the production lab regarding ab82049.
At this point, we are not sure why the protein would not be visible on the gel. Have you repeated the assay, and if...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"