Recombinant Human THAP1 protein (denatured) (ab124553)

製品の概要

  • 製品名Recombinant Human THAP1 protein (denatured)
  • タンパク質長Full length protein
  • 製品の詳細
    Recombinant Human THAP1 protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9NVV9
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MGSHMVQSCS AYGCKNRYDK DKPVSFHKFP LTRPSLCKEW EAAVRRKNFK PTKYSSICSE HFTPDCFKRE CNNKLLKENA VPTIFLCTEP HDKKEDLLEP QEQLPPPPLP PPVSQVDAAI GLLMPPLQTP VNLSVFCDHN YTVEDTMHQR KRIHQLEQQV EKLRKKLKTA QQRCRRQERQ LEKLKEVVHF QKEKDDVSER GYVILPNDYF EIVEVPA
    • 分子量28 kDa including tags
    • 領域1 to 213
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab124553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 85 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 12.01% Urea, 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 1.17% Sodium chloride

関連情報

  • 別名
    • 4833431A01Rik
    • FLJ10477
    • MGC33014
    • Nuclear proapoptotic factor
    • THAP 1
    • THAP domain containing apoptosis associated protein 1
    • THAP domain containing protein 1
    • THAP domain protein 1
    • THAP domain-containing protein 1
    • Thap1
    • THAP1_HUMAN
    see all
  • 機能DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
  • 関連疾患Defects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
  • 配列類似性Belongs to the THAP1 family.
    Contains 1 THAP-type zinc finger.
  • 細胞内局在Nucleus > nucleoplasm. Nucleus > PML body.
  • Information by UniProt

Recombinant Human THAP1 protein (denatured) 画像

  • 15% SDS-PAGE (3 µg loaded)

Recombinant Human THAP1 protein (denatured) (ab124553) 使用論文

ab124553 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab124553.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"