Recombinant human TGF beta Receptor I protein (ab105908)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号P36897
    • 生物種Human
    • 分子量66 kDa including tags
    • 領域80 to 503

特性

Our Abpromise guarantee covers the use of ab105908 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab105908 was determined to be 3 nmol/min/mg.
  • アプリケーション

    Functional Studies

    Western blot

  • 精製度> 90 % Densitometry.
    Purity was determined to be >90% by densitometry.
  • 製品の状態Liquid
  • 備考

    ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • AAT 5
    • AAT5
    • Activin A receptor type II like kinase 53kDa
    • Activin A receptor type II like kinase, 53kD
    • Activin A receptor type II like protein kinase of 53kD
    • activin A receptor type II-like kinase, 53kDa
    • activin A receptor type II-like protein kinase of 53kD
    • Activin receptor like kinase 5
    • Activin receptor-like kinase 5
    • ACVRLK 4
    • ACVRLK4
    • ALK 5
    • ALK-5
    • ALK5
    • LDS1A
    • LDS2A
    • MSSE
    • Serine/threonine protein kinase receptor R4
    • Serine/threonine-protein kinase receptor R4
    • SKR 4
    • SKR4
    • TbetaR I
    • TbetaR-I
    • TGF beta receptor type 1
    • TGF beta receptor type I
    • TGF beta type I receptor
    • TGF-beta receptor type I
    • TGF-beta receptor type-1
    • TGF-beta type I receptor
    • TGFBR 1
    • TGFBR1
    • TGFBR1 protein
    • TGFR 1
    • TGFR-1
    • TGFR1
    • TGFR1_HUMAN
    • Transforming growth factor beta receptor 1
    • Transforming growth factor beta receptor I
    • Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD)
    • transforming growth factor, beta receptor 1
    • transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
    • Transforming growth factor-beta receptor type I
    see all
  • 機能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
  • 組織特異性Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
  • 関連疾患Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A) [MIM:609192]; also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tortuosity and aneurysms, craniosynostosis, hypertelorism, and bifid uvula or cleft palate. Other findings include exotropy, micrognathia and retrognathia, structural brain abnormalities, intellectual deficit, congenital heart disease, translucent skin, joint hyperlaxity and aneurysm with dissection throughout the arterial tree.
    Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 2A (LDS2A) [MIM:608967]. LDS2 is an aortic aneurysm syndrome with widespread systemic involvement. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, diffuse arterial aneurysms and dissections, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. LDS2 is characterized by the absence of craniofacial abnormalities with the exception of bifid uvula that can be present in some patients.
    Defects in TGFBR1 are the cause of aortic aneurysm familial thoracic type 5 (AAT5) [MIM:608967]. Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Phosphorylated at basal levels in the absence of ligand binding. Activated by multiple phosphorylation, mainly in the GS region.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant human TGF beta Receptor I protein 画像

  • Kinase Assay demonstrating specific activity of ab105908 at 3 nmol/min/mg.
  • SDS-PAGE showing ab105908 at approximately 66kDa.

Recombinant human TGF beta Receptor I protein (ab105908) 使用論文

ab105908 has not yet been referenced specifically in any publications.

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