Recombinant Human TCF3 / E2A protein (ab114447)

製品の概要

  • 製品名
    Recombinant Human TCF3 / E2A protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      EREKERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQ AVSVILNLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGL SEAHNPAGHM
    • 分子量
      38 kDa including tags
    • 領域
      545 to 654

特性

Our Abpromise guarantee covers the use of ab114447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AGM8
    • bHLHb21
    • Class B basic helix-loop-helix protein 21
    • E12
    • E2A
    • E2A immunoglobulin enhancer binding factors E12/E47
    • E47
    • Helix loop helix protein HE47
    • Immunoglobulin enhancer-binding factor E12/E47
    • Immunoglobulin transcription factor 1
    • ITF1
    • Kappa-E2-binding factor
    • MGC129647
    • MGC129648
    • Negative vitamin D response element binding protein
    • NOL1-TCF3 fusion
    • TCF-3
    • Tcf3
    • TFE2_HUMAN
    • Transcription factor 3
    • transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
    • transcription factor 3 variant 3
    • Transcription factor E2-alpha
    • Transcription factor ITF-1
    • VDIR
    • VDR interacting repressor
    • vitamin D receptor-interacting repressor
    see all
  • 機能
    Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
  • 関連疾患
    Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1; Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.
  • 配列類似性
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • ドメイン
    the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • 翻訳後修飾
    Phosphorylated following NGF stimulation.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • ab114447 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

参考文献

ab114447 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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