製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q15370
    • 生物種Human
    • 配列MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCIEPFSSPPELP DVMKPQDSGS SANEQAVQ
    • 分子量13 kDa
    • 領域1 to 118

関連製品

特性

Our Abpromise guarantee covers the use of ab117680 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    TCEB2 is purified by standard chromatography techniques and filter sterilized.
  • 製品の状態Liquid
  • 備考For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.02% PMSF, 20% Glycerol

関連情報

  • 別名
    • EloB
    • ELOB_HUMAN
    • Elongin 18 kDa subunit
    • Elongin B
    • Elongin-B
    • RNA polymerase II transcription factor SIII p18 subunit
    • RNA polymerase II transcription factor SIII subunit B
    • SIII
    • SIII p18
    • TCEB 2
    • Tceb2
    • Transcription elongation factor B (SIII) polypeptide 2
    • Transcription elongation factor B polypeptide 2
    see all
  • 機能SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Contains 1 ubiquitin-like domain.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human TCEB2 protein (ab117680) 使用論文

ab117680 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"