製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q15369
    • 生物種Human
    • 配列MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPG QFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIA LELLMAANFLDC
    • 分子量38 kDa including tags
    • 領域1 to 112

特性

Our Abpromise guarantee covers the use of ab114949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    Western blot

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Elo C
    • EloC
    • ELOC_HUMAN
    • Elongin 15 kDa subunit
    • Elongin C
    • Elongin-C
    • ElonginC
    • RNA polymerase II transcription factor SIII subunit C
    • SIII
    • SIII p15
    • TCEB 1
    • tceb1
    • Transcription elongation factor B (SIII) polypeptide 1
    • Transcription elongation factor B polypeptide 1
    see all
  • 機能SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • 組織特異性Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.
  • 配列類似性Belongs to the SKP1 family.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human TCEB1 protein 画像

  • 12.5% SDS-PAGE showing ab114949 at approximately 38.06kDa.
    Stained with Coomassie Blue.

Recombinant Human TCEB1 protein (ab114949) 使用論文

ab114949 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"