製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab82632 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20mM Tris, 10mM Sodium chloride, pH 8

  • 再構成Packaging size : 0.5 mg

関連情報

  • 別名
    • DAP1
    • GAP modifying protein 1
    • GAP-modifying protein 1
    • GMP 1
    • GMP1
    • OFC10
    • PIC 1
    • PIC1
    • SENP2
    • Sentrin
    • Sentrin 1
    • Small ubiquitin related modifier 1
    • Small ubiquitin-like modifier 1
    • Small ubiquitin-related modifier 1
    • SMT3
    • SMT3 homolog 3
    • SMT3 suppressor of mif two 3 homolog 1
    • SMT3, yeast, homolog 3
    • Smt3C
    • SMT3H3
    • SUMO-1
    • SUMO1
    • SUMO1_HUMAN
    • Ubiquitin homology domain protein PIC1
    • Ubiquitin Like 1
    • Ubiquitin like protein SMT3C
    • Ubiquitin like protein UBL1
    • Ubiquitin-homology domain protein PIC1
    • Ubiquitin-like protein SMT3C
    • Ubiquitin-like protein UBL1
    • UBL 1
    • UBL1
    see all
  • 機能Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.
  • 関連疾患Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:613705]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.
  • 配列類似性Belongs to the ubiquitin family. SUMO subfamily.
    Contains 1 ubiquitin-like domain.
  • 翻訳後修飾Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
    Polymeric SUMO1 chains undergo polyubiquitination by RNF4.
  • 細胞内局在Nucleus membrane. Nucleus speckle. Cytoplasm. Recruited by BCL11A into the nuclear body.
  • Information by UniProt

Recombinant Human Sumo 1 protein 画像

  • ab82632 at 1µg on SDS-PAGE.

Recombinant Human Sumo 1 protein (ab82632) 使用論文

ab82632 has not yet been referenced specifically in any publications.

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