製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY
    • 領域
      1 to 303

特性

Our Abpromise guarantee covers the use of ab82791 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

  • 精製度
    > 90 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 5mM DTT, 20mM Tris HCl, pH 7.5

関連情報

  • 別名
    • Antigen NY CO 7
    • Antigen NY-CO-7
    • C terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70 interacting protein
    • Carboxy terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70p interacting protein
    • CHIP
    • CHIP_HUMAN
    • CLL associated antigen KW 8
    • CLL-associated antigen KW-8
    • E3 ubiquitin protein ligase CHIP
    • E3 ubiquitin-protein ligase CHIP
    • Heat shock protein A binding protein 2 (c terminal)
    • HSPABP2
    • NY CO 7
    • PP1131
    • SDCCAG7
    • Serologically defined colon cancer antigen 7
    • STIP1 homology and U Box containing protein 1
    • STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase
    • STIP1 homology and U box-containing protein 1
    • STUB 1
    • STUB1
    • UBOX 1
    • UBOX1
    see all
  • 機能
    E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
  • 組織特異性
    Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Contains 3 TPR repeats.
    Contains 1 U-box domain.
  • ドメイン
    The TPR domain is essential for ubiquitination mediated by UBE2D1.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

Recombinant Human STUB1 protein 画像

  • 15% SDS-PAGE showing ab82791 at approximately 34.8kDa (3µg).

Recombinant Human STUB1 protein (ab82791) 使用論文

ab82791 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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