製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab60885 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 製品の状態Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 0610042I06Rik
    • EC 2.7.11.1
    • FLJ90748
    • Kinase responsive to stress 1
    • KRS1
    • Mammalian STE20 like protein kinase 2
    • Mammalian STE20-like protein kinase 2
    • Mammalian sterile 20-like 2
    • Mess1
    • MST
    • MST-2
    • MST2
    • Mst3
    • Serine/threonine kinase 3 (STE20 homolog, yeast)
    • Serine/threonine kinase 3 (Ste20, yeast homolog)
    • Serine/threonine protein kinase 3
    • Serine/threonine protein kinase Krs1
    • Serine/threonine-protein kinase 3
    • Serine/threonine-protein kinase Krs-1
    • STE20 like kinase MST2
    • STE20-like kinase MST2
    • Stk3
    • STK3_HUMAN
    • wu:fc19e11
    • zgc:55383
    see all
  • 機能Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.
  • 組織特異性Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SARAH domain.
  • 細胞内局在Cytoplasm. Nucleus. The caspase-cleaved form cycles between nucleus and cytoplasm.
  • Information by UniProt

Recombinant human STK3 protein 画像

  • Sample Kinase Activity Plot.
  • ab60885 on SDS-PAGE, MW ~87 kDa.

Recombinant human STK3 protein (ab60885) 使用論文

ab60885 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab60885.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"