製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF
    • 領域1 to 98

特性

Our Abpromise guarantee covers the use of ab78799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    Purity is > 98% by SDS PAGE. ab78799 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Sodium chloride, 20mM Tris, pH 8.0

関連情報

  • 別名
    • CHROW21
    • CPI B
    • CPI-B
    • CST 6
    • CST6
    • CSTB
    • Cystatin B
    • Cystatin B (stefin B)
    • Cystatin-B
    • CYTB
    • CYTB_HUMAN
    • EPM1
    • EPM1A
    • Liver thiol proteinase inhibitor
    • PME
    • Stefin-B
    • STF B
    • STFB
    • ULD
    see all
  • 機能This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
  • 関連疾患Defects in CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) [MIM:254800]. EPM1 is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The onset, occurring between 6 and 13 years of age, is characterized by convulsions. Myoclonus begins 1 to 5 years later. The twitchings occur predominantly in the proximal muscles of the extremities and are bilaterally symmetrical, although asynchronous. At first small, they become late in the clinical course so violent that the victim is thrown to the floor. Mental deterioration and eventually dementia develop.
  • 配列類似性Belongs to the cystatin family.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human Stefin B protein 画像

  • 15% SDS-PAGE showing ab78799 at approximately 13kDa (3µg).

Recombinant Human Stefin B protein (ab78799) 使用論文

This product has been referenced in:
  • Mandal P  et al. H3 clipping activity of glutamate dehydrogenase is regulated by stefin B and chromatin structure. FEBS J 281:5292-308 (2014). Read more (PubMed: 25263734) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab78799.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"