Recombinant Human Stathmin 1 protein (ab125559)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P16949
    • 生物種Human
    • 分子量19 kDa
    • 領域1 to 149
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125559 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度> 90 % Densitometry.
    ab125559 is >90% pure.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 1.75% Sodium chloride, 25% Glycerol, 0.004% DTT, 0.81% Sodium phosphate, 0.002% PMSF

関連情報

  • 別名
    • C1orf215
    • Lag
    • LAP 18
    • LAP18
    • Leukemia associated phosphoprotein p18
    • Leukemia-associated phosphoprotein p18
    • Metablastin
    • Oncoprotein 18
    • OP 18
    • Op18
    • p18
    • p19
    • Phosphoprotein 19
    • Phosphoprotein p19
    • pp17
    • pp19
    • PR22
    • Pr22 protein
    • Prosolin
    • Protein Pr22
    • SMN
    • Stathmin
    • Stathmin1
    • STMN 1
    • Stmn1
    • STMN1_HUMAN
    see all
  • 機能Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
  • 組織特異性Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
  • 配列類似性Belongs to the stathmin family.
    Contains 1 SLD (stathmin-like) domain.
  • 翻訳後修飾Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • 細胞内局在Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant Human Stathmin 1 protein 画像

  • SDS PAGE analysis of ab125559 (Stathmin 1 protein).

Recombinant Human Stathmin 1 protein (ab125559) 使用論文

ab125559 has not yet been referenced specifically in any publications.

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