This product is an active protein and may elicit a biological response in vivo, handle with caution.
Serine/arginine rich protein specific kinase 1
Serine/arginine rich splicing factor kinase 1
Serine/arginine-rich protein-specific kinase 1
Serine/threonine protein kinase SRPK1
Serine/threonine-protein kinase SRPK1
SFRS protein kinase 1
SR protein kinase 1
SR protein specific kinase 1
SR-protein-specific kinase 1
機能Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
組織特異性Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2.
配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Contains 1 protein kinase domain.