Recombinant Human SREBP2 protein (ab114215)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      QAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDS VGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFT
    • 分子量
      37 kDa including tags
    • 領域
      801 to 900

特性

Our Abpromise guarantee covers the use of ab114215 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AI608257
    • bHLHd2
    • Class D basic helix-loop-helix protein 2
    • OTTHUMP00000028740
    • Processed sterol regulatory element-binding protein 2
    • SRBP2_HUMAN
    • SREBF 2
    • Srebf2
    • SREBF2 protein
    • SREBP 2
    • SREBP-2
    • SREBP2
    • SREBP2gc
    • sterol regulatory element binding factor 2
    • Sterol regulatory element binding protein 2
    • Sterol regulatory element binding transcription factor 2
    • Sterol regulatory element-binding transcription factor 2
    see all
  • 機能
    Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
  • 組織特異性
    Ubiquitously expressed in adult and fetal tissues.
  • 配列類似性
    Belongs to the SREBP family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • 翻訳後修飾
    At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
  • 細胞内局在
    Nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle > COPII-coated vesicle membrane. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
  • Information by UniProt

画像

  • ab114215 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

参考文献

ab114215 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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