製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P35270
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMEGGLGRAVCLLTGASRGFGRTLAPLLASL LSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLL GALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTS MLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGK LVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
    • 分子量30 kDa including tags
    • 領域1 to 261
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab117189 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab117189 is purified by proprietary chromatographic techniques.
  • 製品の状態Liquid
  • 備考Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituent: 0.32% Tris HCl

関連情報

  • 別名
    • OTTHUMP00000160199
    • SDR38C1
    • Sepiapterin reductase
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase)
    • Short chain dehydrogenase/reductase family 38C, member 1
    • SPR
    • SPRE_HUMAN
    see all
  • 機能Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • 関連疾患Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • 配列類似性Belongs to the sepiapterin reductase family.
  • 翻訳後修飾In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human SPR protein (ab117189) 使用論文

ab117189 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"