Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.
Protein modification; protein ubiquitination.
Belongs to the Tdpoz family. Contains 1 BTB (POZ) domain. Contains 1 MATH domain.