製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P23497
    • 生物種Human
    • 配列MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLY DIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLV PVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHD KLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPSGSPSHAGTTPP ENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQ IAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEK PFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRS EPVINNDNPLESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVI GQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF SSSDFSDLSNGEELQETCSSSLRRGSGKED
    • 分子量79 kDa including tags
    • 領域1 to 480

特性

Our Abpromise guarantee covers the use of ab114587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • DKFZp686E07254
    • FLJ00340
    • FLJ34579
    • Lysp100b
    • Nuclear antigen Sp100
    • Nuclear autoantigen Sp 100
    • Nuclear autoantigen Sp-100
    • Nuclear autoantigen Sp100
    • Nuclear dot associated Sp100 protein
    • Nuclear dot-associated Sp100 protein
    • SP 100
    • SP100
    • SP100 HMG nuclear autoantigen
    • SP100 nuclear antigen
    • SP100_HUMAN
    • Speckled 100 kDa
    see all
  • 機能May play a role in the control of gene expression.
  • 組織特異性Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
  • 配列類似性Contains 2 HMG box DNA-binding domains.
    Contains 1 HSR domain.
    Contains 1 SAND domain.
  • ドメインThe HSR domain is important for the nuclear body targeting as well as for the dimerization.
    Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
  • 翻訳後修飾Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.
  • 細胞内局在Nucleus > PML body. Found in the nuclear body, also known as nuclear domain 10 (ND10), PML oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear localization of the isoforms.
  • Information by UniProt

Recombinant Human SP100 protein 画像

  • 12.5% SDS-PAGE showing ab114587 at approximately 78.87kDa stained with Coomassie Blue.

Recombinant Human SP100 protein (ab114587) 使用論文

ab114587 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114587.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"