製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY LEHHHHHH
    • 領域1 to 200

特性

Our Abpromise guarantee covers the use of ab93948 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab93948 was purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 40% Glycerol, 200mM Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

関連情報

  • 別名
    • ANOP3
    • cb236
    • Delta EF2a
    • lcc
    • MCOPS3
    • MGC148683
    • MGC2413
    • RGD1565646
    • Sex determining region Y box 2
    • SOX 2
    • Sox2
    • SOX2_HUMAN
    • SRY (sex determining region Y) box 2
    • SRY box containing gene 2
    • SRY related HMG box 2
    • SRY related HMG box gene 2
    • SRY-box 2
    • Transcription factor SOX 2
    • Transcription factor SOX-2
    • ysb
    see all
  • 機能Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
  • 関連疾患Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
  • 配列類似性Contains 1 HMG box DNA-binding domain.
  • 翻訳後修飾Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human SOX2 protein 画像

  • 15% SDS-PAGE analysis of ab93948 (3µg)

Recombinant Human SOX2 protein (ab93948) 使用論文

ab93948 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"