The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Sox2-TAT is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Sex determining region Y box 2
SRY (sex determining region Y) box 2
SRY box containing gene 2
SRY related HMG box 2
SRY related HMG box gene 2
Transcription factor SOX 2
Transcription factor SOX-2
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
Contains 1 HMG box DNA-binding domain.
Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.