Recombinant human Snf1lk2 protein (ab89856)

製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Insect cells
  • アミノ酸配列
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab89856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The specific activity of ab89856 was determined to be 112 nmol/min/mg.
  • アプリケーション

    SDS-PAGE

    Western blot

    Functional Studies

  • 製品の状態
    Liquid
  • 備考

    ab204852 (AMARA substrate peptide for SIK + AMPK) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • DKFZp434K1115
    • EC 2.7.11.1
    • KIAA0781
    • LOH11CR1I
    • QIK
    • Qin induced kinase
    • Qin-induced kinase
    • Salt inducible kinase 2
    • Salt inducible protein kinase 2
    • Salt inducible serine/threonine kinase 2
    • Salt-inducible protein kinase 2
    • Serine/threonine protein kinase SIK2
    • Serine/threonine protein kinase SNF1 like kinase 2
    • Serine/threonine-protein kinase SIK2
    • Serine/threonine-protein kinase SNF1-like kinase 2
    • SIK 2
    • SIK-2
    • SIK2
    • SIK2_HUMAN
    • SNF1 like kinase
    • SNF1 like kinase 2
    • SNF1LK2
    see all
  • 機能
    Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
  • 配列類似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

画像

  • SDS-PAGE showing ab89856 at approximately 150kDa
  • Kinase Assay demonstrating specific activity of ab89856

参考文献

ab89856 has not yet been referenced specifically in any publications.

レビューと Q&A

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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