製品の概要

製品の詳細

  • 由来Recombinant
  • 由来HEK 293 cells
  • アミノ酸配列
    • 生物種Human
    • 配列ACPAQCSCSG STVDCHGLAL RSVPRNIPRN TERLDLNGNN ITRITKTDFA GLRHLRVLQL MENKISTIER GAFQDLKELE RLRLNRNHLQ LFPELLFLGT AKLYRLDLSE NQIQAIPRKA FRGAVDIKNL QLDYNQISCI EDGAFRALRD LEVLTLNNNN ITRLSVASFN HMPKLRTFRL HSNNLYCDCH LAWLSDWLRQ RPRVGLYTQC MGPSHLRGHN VAEVQKREFV CSGHQSFMAP SCSVLHCPAA CTCSNNIVDC RGKGLTEIPT NLPETITEIR LEQNTIKVIP PGAFSPYKKL RRIDLSNNQI SELAPDAFQG LRSLNSLVLY GNKITELPKS LFEGLFSLQL LLLNANKINC LRVDAFQDLH NLNLLSLYDN KLQTIAKGTF SPLRAIQTMH LAQNPFICDC HLKWLADYLH TNPIETSGAR CTSPRRLANK RIGQIKSKKF RCSAKEQYFI PGTEDYRSKL SGDCFADLAC PEKCRCEGTT VDCSNQKLNK IPEHIPQYTA ELRLNNNEFT VLEATGIFKK LPQLRKINFS NNKITDIEEG AFEGASGVNE ILLTSNRLEN VQHKMFKGLE SLKTLMLRSN RITCVGNDSF IGLSSVRLLS LYDNQITTVA PGAFDTLHSL STLNLLANPF NCNCYLAWLG EWLRKKRIVT GNPRCQKPYF LKEIPIQDVA IQDFTCDDGN DDNSCSPLSR CPTECTCLDT VVRCSNKGLK VLPKGIPRDV TELYLDGNQF TLVPKELSNY KHLTLIDLSN NRISTLSNQS FSNMTQLLTL ILSYNRLRCI PPRTFDGLKS LRLLSLHGND ISVVPEGAFN DLSALSHLAI GANPLYCDCN MQWLSDWVKS EYKEPGIARC AGPGEMADKL LLTTPSKKFT CQGPVDVNIL AKCNPCLSNP CKNDGTCNSD PVDFYRCTCP YGFKGQDCDV PIHACISNPC KHGGTCHLKE GEEDGFWCIC ADGFEGENCE VNVDDCEDND CENNSTCVDG INNYTCLCPP EYTGELCEEK LDFCAQDLNP CQHDSKCILT PKGFKCDCTP GYVGEHCDID FDDCQDNKCK NGAHCTDAVN GYTCICPEGY SGLFCEFSPP MV
    • 領域27 to 1118

関連製品

特性

Our Abpromise guarantee covers the use of ab82131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • エンドトキシン・レベル< 0.100 Eu/µg
  • 精製度> 95 % SDS-PAGE.
    Purity is greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg)
  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • Drad 1
    • E030015M03Rik
    • E130320P19Rik
    • FLJ14420
    • OTTHUMP00000158695
    • OTTHUMP00000217852
    • OTTHUMP00000217853
    • OTTHUMP00000217854
    • Slil 3
    • Slil3
    • Slit 2
    • Slit homolog 2
    • Slit homolog 2 (Drosophila)
    • Slit homolog 2 protein
    • Slit homolog 2 protein C-product
    • Slit-2
    • Slit2
    • SLIT2_HUMAN
    see all
  • 機能Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
  • 組織特異性Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined.
  • 配列類似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 7 EGF-like domains.
    Contains 1 laminin G-like domain.
    Contains 20 LRR (leucine-rich) repeats.
    Contains 4 LRRCT domains.
    Contains 4 LRRNT domains.
  • ドメインThe leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro.
  • 細胞内局在Secreted. The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
  • Information by UniProt

Recombinant Human Slit2 protein (ab82131) 使用論文

This product has been referenced in:

See all 3 Publications for this product

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