Recombinant Human SLC12A1 protein (ab114560)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q13621
    • 生物種Human
    • 配列AKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRP SLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQA
    • 分子量36 kDa including tags
    • 領域80 to 172

特性

Our Abpromise guarantee covers the use of ab114560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • BSC1
    • Bumetanide sensitive sodium 3
    • Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
    • Kidney specific Na K Cl symporter
    • Kidney-specific Na-K-Cl symporter
    • MGC48843
    • Na K 2Cl cotransporter
    • NKCC2
    • potassiumchloride cotransporter 2
    • S12A1_HUMAN
    • Slc12a1
    • sodium potassium chloride cotransporter 2
    • solute carrier family 12 (sodium/potassium/chloride transporters)
    • Solute carrier family 12 member 1
    see all
  • 機能Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
  • 組織特異性Kidney specific.
  • 関連疾患Defects in SLC12A1 are the cause of Bartter syndrome type 1 (BS1) [MIM:601678]. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS1 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS1 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
  • 配列類似性Belongs to the SLC12A transporter family.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant Human SLC12A1 protein 画像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human SLC12A1 protein (ab114560) 使用論文

ab114560 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"