Recombinant Human SLAM / CD150 protein (ab125998)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      11 kDa
    • 領域
      21 to 117

特性

Our Abpromise guarantee covers the use of ab125998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成
    Reconstitute with water to desired concentration.

関連情報

  • 別名
    • 4933415F16
    • AA177906
    • CD 150
    • CD150
    • CD150 antigen
    • CDw150
    • Estm51
    • Ipo 3
    • IPO-3
    • Ipo3
    • MGC151472
    • MGC151476
    • OTTHUMP00000025670
    • OTTHUMP00000060252
    • RGD1560634
    • Signaling lymphocytic activation molecule
    • Signaling lymphocytic activation molecule family member 1
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_a
    • Signaling lymphocytic activation molecule family member 1, isoform CRA_b
    • Signaling lymphocytic activation molecule precursor
    • Slaf1
    • SLAF1_HUMAN
    • SLAM family, member 1
    • Slamf 1
    • SLAMF1
    • SLAMF1 protein
    see all
  • 機能
    High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
  • 組織特異性
    Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
  • 配列類似性
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • ドメイン
    The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.
  • 翻訳後修飾
    Phosphorylated by FYN.
  • 細胞内局在
    Cell membrane. Present on the surface of B-cells and T-cells.
  • Information by UniProt

参考文献

ab125998 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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