製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      EHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNT LAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQ VAVAHVSETI
    • 分子量
      38 kDa including tags
    • 領域
      176 to 285

特性

Our Abpromise guarantee covers the use of ab114386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    ab114386 is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • CDK2/Cyclin A associated protein p45
    • Cyclin A/CDK2 associated protein p45
    • Cyclin-A/CDK2-associated protein p45
    • F box protein Skp2
    • F box/LRR repeat protein 1
    • F-box protein Skp2
    • F-box/LRR-repeat protein 1
    • FBL 1
    • FBL1
    • FBXL 1
    • FBXL1
    • FLB 1
    • FLB1
    • MGC1366
    • p45
    • p45skp2
    • S phase kinase associated protein 2
    • S phase kinase associated protein 2 (p45)
    • S-phase kinase-associated protein 2
    • S-phase kinase-associated protein 2 E3 ubiquitin protein ligase
    • SKP 2
    • Skp2
    • SKP2_HUMAN
    see all
  • 機能
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Contains 1 F-box domain.
    Contains 9 LRR (leucine-rich) repeats.
  • Information by UniProt

画像

  • ab114386 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.

参考文献

ab114386 has not yet been referenced specifically in any publications.

レビューと Q&A

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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