NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Regulatory protein SIR2 homolog 3
Silent mating type information regulation 2 S.cerevisiae homolog 3
Sir 2 like 3
SIR 2 like protein 3
Sir2 like 3
SIR2 like protein 3
SIR2-like protein 3
Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae)
Sirtuin type 3
機能NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
配列類似性Belongs to the sirtuin family. Class I subfamily. Contains 1 deacetylase sirtuin-type domain.
翻訳後修飾Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.