Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae)
Sirtuin type 2
機能NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
組織特異性Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
配列類似性Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain.
発生段階Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
翻訳後修飾Phosphorylated at the G2/M transition of the cell cycle.
細胞内局在Cytoplasm > cytoskeleton. Colocalizes with microtubules.