製品の概要

  • 製品名Recombinant Human SI protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P14410
    • 生物種Human
    • 配列DGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGK GTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINW
    • 分子量37 kDa including tags
    • 領域1728 to 1826

関連製品

特性

Our Abpromise guarantee covers the use of ab114715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Isomaltase
    • MGC131621
    • MGC131622
    • Oligosaccharide alpha 1, 6 glucosidase
    • SI
    • sucrase isomaltase
    • sucrase isomaltase alpha glucosidase
    • Sucrase-isomaltase, intestinal
    • SUIS_HUMAN
    see all
  • 機能Plays an important role in the final stage of carbohydrate digestion.
  • 組織特異性Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
  • 関連疾患Defects in SI are the cause of congenital sucrase-isomaltase deficiency (CSID) [MIM:222900]; also known as disaccharide intolerance I. CSID is an autosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
  • 配列類似性Belongs to the glycosyl hydrolase 31 family.
    Contains 2 P-type (trefoil) domains.
  • 翻訳後修飾The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.
    Sulfated.
  • 細胞内局在Apical cell membrane. Brush border.
  • Information by UniProt

Recombinant Human SI protein 画像

  • 12.5% SDS-PAGE showing ab114715 at approximately 36.52 kDa stained with Coomassie Blue.

Recombinant Human SI protein (ab114715) 使用論文

ab114715 has not yet been referenced specifically in any publications.

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