Recombinant Human Shwachman Bodian-Diamond syndrome protein (ab99957)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9Y3A5
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMSIFTPTNQIRLTNVAVVRMKRAGKRFEIA CYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQ TEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTV ILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPV NEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKG KGSLEVLNLKDVEEGDEKFE
    • 分子量31 kDa including tags
    • 領域1 to 250
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab99957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab99957 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 2mM DTT, 0.1mM EDTA, pH 8.0

関連情報

  • 別名
    • 4733401P19Rik
    • AI836084
    • CGI 97
    • CGI-97
    • FLJ10917
    • MGC105922
    • Protein 22A3
    • Ribosome maturation protein SBDS
    • sbds
    • SBDS_HUMAN
    • SDS
    • Shwachman Bodian Diamond syndrome protein
    • Shwachman Bodian Diamond syndrome protein homolog
    • Shwachman-Bodian-Diamond syndrome protein
    • SWDS
    see all
  • 機能Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
  • 組織特異性Widely expressed.
  • 関連疾患Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS) [MIM:260400]. SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.
  • 配列類似性Belongs to the SDO1/SBDS family.
  • 細胞内局在Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle. Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase.
  • Information by UniProt

Recombinant Human Shwachman Bodian-Diamond syndrome protein 画像

  • 15% SDS-PAGE showing ab99957 (3µg).

Recombinant Human Shwachman Bodian-Diamond syndrome protein (ab99957) 使用論文

ab99957 has not yet been referenced specifically in any publications.

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