SET domain and mariner transposase fusion gene containing protein
SET domain and mariner transposase fusion gene-containing protein
機能Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
組織特異性Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
配列類似性In the N-terminal section; belongs to the histone-lysine methyltransferase family. In the C-terminal section; belongs to the mariner transposase family. Contains 1 post-SET domain. Contains 1 pre-SET domain. Contains 1 SET domain.
ドメインThe mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue.