The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Chondroitin sulfate proteoglycan core protein
Cytolytic granule proteoglycan core protein
Hematopoetic proteoglycan core protein
Mastocytoma proteoglycan core protein
PG19 core protein
Platelet proteoglycan core protein
platelet proteoglycan protein core
PLATELET PROTEOGLYCAN PROTEIN CORE; PPG
proteoglycan 1, secretory granule
Proteoglycan 10K core protein
Proteoglycan peptide core protein
PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE
secretory granule proteoglycan 1
Secretory granule proteoglycan core peptide
Secretory granule proteoglycan core protein
機能Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
配列類似性Belongs to the serglycin family.
翻訳後修飾O-glcosylated; contains chondroitin sulfate and heparan sulfate.
細胞内局在Cytoplasmic granule. Secreted > extracellular space. Golgi apparatus. Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.