製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号P53778
    • 生物種Human
    • 分子量71 kDa including tags
    • 領域1 to 367

関連製品

特性

Our Abpromise guarantee covers the use of ab125651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The specific activity of ab125651 was determined to be 220 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 精製度> 90 % Densitometry.
    Purity was determined to be >90% by densitometry.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • ERK 3
    • ERK 5
    • ERK 6
    • ERK-6
    • ERK3
    • ERK6
    • Extracellular signal-regulated kinase 6
    • MAP kinase 12
    • MAP kinase p38 gamma
    • MAPK 12
    • Mapk12
    • Mitogen Activated Protein Kinase 12
    • Mitogen activated protein kinase 3
    • Mitogen activated protein kinase p38 gamma
    • Mitogen-activated protein kinase 12
    • Mitogen-activated protein kinase p38 gamma
    • MK12_HUMAN
    • P38 GAMMA
    • P38GAMMA
    • PRKM12
    • SAPK 3
    • SAPK-3
    • SAPK3
    • Stress Activated Protein Kinase 3
    • Stress-activated protein kinase 3
    see all
  • 機能Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
  • 組織特異性Highly expressed in skeletal muscle and heart.
  • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • ドメインThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻訳後修飾Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
  • 細胞内局在Cytoplasm. Mitochondrion. Mitochondrial when associated with SH3BP5.
  • Information by UniProt

Recombinant human SAPK3 protein 画像

  • SDS-PAGE analysis of ab125651.
  • The specific activity of ab125651 was determined to be 220 nmol/min/mg by Kinase Assay.

Recombinant human SAPK3 protein (ab125651) 使用論文

ab125651 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125651.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"