製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMSSPPPARSGFYRQEVTKTAWEVRAVYRDL QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD HLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSF DDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL
    • 分子量
      44 kDa including tags
    • 領域
      1 to 367
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab117221 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度
    > 95 % SDS-PAGE.
    ab117221 is purified using conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • ERK 6
    • ERK-6
    • ERK6
    • Extracellular signal-regulated kinase 6
    • MAP kinase 12
    • MAP kinase p38 gamma
    • MAPK 12
    • Mapk12
    • Mitogen Activated Protein Kinase 12
    • Mitogen activated protein kinase p38 gamma
    • Mitogen-activated protein kinase 12
    • Mitogen-activated protein kinase p38 gamma
    • MK12_HUMAN
    • P38 GAMMA
    • P38GAMMA
    • PRKM12
    • SAPK 3
    • SAPK-3
    • SAPK3
    • Stress Activated Protein Kinase 3
    • Stress-activated protein kinase 3
    see all
  • 機能
    Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
  • 組織特異性
    Highly expressed in skeletal muscle and heart.
  • 配列類似性
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • ドメイン
    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻訳後修飾
    Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
  • 細胞内局在
    Cytoplasm. Mitochondrion. Mitochondrial when associated with SH3BP5.
  • Information by UniProt

Recombinant Human SAPK3 protein 画像

  • 15% SDS-PAGE showing ab117221 at approximately 44.1kDa (3µg).

Recombinant Human SAPK3 protein (ab117221) 使用論文

ab117221 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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