製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P34925
    • 生物種Human
    • 配列ELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVP SETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVF RVELSCTGKV
    • 分子量38 kDa including tags
    • 領域54 to 163

特性

Our Abpromise guarantee covers the use of ab114531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • D3S3195
    • ERK 3
    • Hydroxyaryl protein kinase
    • JTK 5
    • JTK 5A
    • JTK5
    • JTK5A
    • JTK5A protein tyrosine kinase
    • receptor like tyrosine kinase
    • receptor like tyrosine kinase precursor
    • Ryk
    • RYK 1
    • RYK_HUMAN
    • RYK1
    • Tyrosine protein kinase RYK
    • Tyrosine protein kinase RYK precursor
    • Tyrosine-protein kinase RYK
    • Vik
    see all
  • 機能May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
  • 組織特異性Observed in all the tissues examined.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 protein kinase domain.
    Contains 1 WIF domain.
  • ドメインThe extracellular WIF domain is responsible for Wnt binding.
  • 翻訳後修飾Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
  • 細胞内局在Membrane. Nucleus. Cytoplasm. In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
  • Information by UniProt

Recombinant Human RYK protein 画像

  • 12.5% SDS-PAGE showing ab114531 at approximately 37.73kDa stained with Coomassie Blue.

Recombinant Human RYK protein (ab114531) 使用論文

ab114531 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"