製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q13950
    • 生物種Human
    • 配列NPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPS IHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKSQAGA
    • 分子量37 kDa including tags
    • 領域251 to 350

特性

Our Abpromise guarantee covers the use of ab112258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Acute myeloid leukemia 3 protein
    • Alpha subunit 1
    • AML3
    • CBF alpha 1
    • CBF-alpha-1
    • CBFA1
    • CCD
    • CCD1
    • Cleidocranial dysplasia 1
    • Core binding factor
    • Core binding factor runt domain alpha subunit 1
    • Core binding factor subunit alpha 1
    • Core-binding factor subunit alpha-1
    • MGC120022
    • MGC120023
    • Oncogene AML 3
    • Oncogene AML-3
    • OSF 2
    • OSF-2
    • OSF2
    • Osteoblast specific transcription factor 2
    • Osteoblast-specific transcription factor 2
    • OTTHUMP00000016533
    • PEA2 alpha A
    • PEA2-alpha A
    • PEA2aA
    • PEBP2 alpha A
    • PEBP2-alpha A
    • PEBP2A1
    • PEBP2A2
    • PEBP2aA
    • PEBP2aA1
    • Polyomavirus enhancer binding protein 2 alpha A subunit
    • Polyomavirus enhancer-binding protein 2 alpha A subunit
    • Runt domain
    • Runt related transcription factor 2
    • Runt-related transcription factor 2
    • RUNX2
    • RUNX2_HUMAN
    • SL3 3 enhancer factor 1 alpha A subunit
    • SL3-3 enhancer factor 1 alpha A subunit
    • SL3/AKV core binding factor alpha A subunit
    • SL3/AKV core-binding factor alpha A subunit
    see all
  • 機能Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
  • 組織特異性Specifically expressed in osteoblasts.
  • 関連疾患Defects in RUNX2 are the cause of cleidocranial dysplasia (CLCD) [MIM:119600]; also known as cleidocranial dysostosis (CCD). CLCD is an autosomal dominant skeletal disorder with high penetrance and variable expressivity. It is due to defective endochondral and intramembranous bone formation. Typical features include hypoplasia/aplasia of clavicles, patent fontanelles, wormian bones (additional cranial plates caused by abnormal ossification of the calvaria), supernumerary teeth, short stature, and other skeletal changes. In some cases defects in RUNX2 are exclusively associated with dental anomalies.
  • 配列類似性Contains 1 Runt domain.
  • ドメインA proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites.
  • 翻訳後修飾Phosphorylated; probably by MAP kinases (MAPK) (By similarity). Isoform 3 is phosphorylated on Ser-340.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human RUNX2 protein 画像

  • Coomassie Blue stained 12.5% SDS page analysis of ab112258

Recombinant Human RUNX2 protein (ab112258) 使用論文

ab112258 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"