製品の概要

  • 製品名
    Recombinant Human RRAD protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      VYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIVVDGEEASL MVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRA RQTDDVPIIL
    • 分子量
      38 kDa including tags
    • 領域
      91 to 200

特性

Our Abpromise guarantee covers the use of ab114746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • GTP binding protein RAD
    • GTP-binding protein RAD
    • RAD
    • RAD_HUMAN
    • RAD1
    • RAS (RAD and GEM) like GTP binding 3
    • Ras associated with diabetes
    • Ras related associated with diabetes
    • REM3
    • RRAD
    see all
  • 機能
    May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
  • 組織特異性
    Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
  • 配列類似性
    Belongs to the small GTPase superfamily. RGK family.
  • 細胞内局在
    Cell membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab114746 at approximately 37.73kDa.
    Stained with Coomassie Blue.

参考文献

ab114746 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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