製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種
      Human
    • 領域
      1 to 299

関連製品

特性

Our Abpromise guarantee covers the use of ab60879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 製品の状態
    Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • CARD 3
    • CARD carrying kinase
    • CARD containing ICE associated kinase
    • CARD containing IL 1 beta ICE kinase
    • CARD containing IL1 beta ICE kinase
    • CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase
    • CARD containing interleukin 1 beta converting enzyme associated kinase
    • CARD-containing IL-1 beta ICE-kinase
    • CARD-containing interleukin-1 beta-converting enzyme-associated kinase
    • CARD3
    • CARDIAK
    • CCK
    • CLARP kinase
    • GIG 30
    • GIG30
    • Growth inhibiting gene 30
    • Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase
    • Receptor interacting protein 2
    • Receptor interacting serine threonine kinase 2
    • Receptor interacting serine/threonine protein kinase 2
    • Receptor-interacting protein 2
    • Receptor-interacting serine/threonine-protein kinase 2
    • RICK
    • RIP 2
    • RIP like interacting CLARP kinase
    • RIP-2
    • RIP-like-interacting CLARP kinase
    • RIPK 2
    • Ripk2
    • RIPK2_HUMAN
    • TNFRSF
    • Tyrosine-protein kinase RIPK2
    • UNQ277/PRO314/PRO34092
    see all
  • 機能
    Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
  • 組織特異性
    Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
  • 配列類似性
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
    Contains 1 CARD domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt

画像

  • Sample Kinase Activity Plot.
  • ab60879 on SDS-PAGE, MW ~59 kDa.

参考文献

ab60879 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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